LAESI Mass Spectrometry Imaging of Contact Lens Spoilage

摘要

The LAESI DP-1000 Direct Ionization System is a powerful tool for the mass spectrometry imaging analysis of contact lenses for the characterization of lens composition and spoilage. LAESI-MSI is useful for the analysis of compounds in and on contact lenses whether they are inherent or have accumulated during wear. (1) Lipids (2) Proteins (3) Materials 3D LAESI-MSI delivers distributional data otherwise currently unavailable to researchers, capturing information through the depth of a sample. Distribution information for molecules from a wide variety of classes is generated by ProteaPlot and displayed in both 2D and 3D map formats. Future studies: (1) On-lens digestion and tandem mass spectrometry with high mass accuracy to aid in the identification of proteins, lipids, and small molecules. (2) Analysis of lens calculi (jelly bumps).