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Functional characterization of ubiquitination profile changes induced by oncogenic protein NPM-ALK in ALK~(+) anaplastic large cell lymphoma cells

机译:致癌蛋白NPM-ALK诱导ubiquitination曲线变化的功能性表征ALK〜(+)促进大细胞淋巴瘤细胞

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摘要

We employed tandem affinity purification and mass spectrometry to comprehensively determine NPM-ALK induced global ubiquitin profile changes; 280 ubiquitinated proteins from HB-ubiquitin transfected Karpas 299 were identified and13 ubiquitination sites were determined.
机译:我们使用串联亲和纯化和质谱法以全面地确定NPM-ALK诱导的全球泛素型材变化; 鉴定了280来自HB-Ubiquitin转染的karpas 299的普适蛋白质,并测定了13个泛素化位点。

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