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Determination of Ethinyl Estradiol in Human Plasma by Dansyl Chloride Derivatization Followed by Automated On-Line SPE Combined with LC/MS/MS

机译:用丹酰氯衍生化,随后将甲酰氯衍生物中的乙炔雌二醇用LC / MS / MS与LC / MS / MS相结合

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摘要

A robust, specific, and simple assay for the analysis of ethinyl estradiol in human plasma has been validated. On-line SPE is an effective clean up step to achieve specificity for dansyl chloride derivitized ethinyl estradiol. The method is suitable to quantify human plasma in pharmacokinetic studies.
机译:验证了用于分析人血浆中乙炔雌二醇的鲁棒,具体和简单的测定。 在线SPE是一种有效的清洁步骤,以达到丹氯衍生乙炔雌二醇的特异性。 该方法适用于量化药代动力学研究的人血浆。

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