Comprehensive Analysis of Glycosylation Patterns of Human Plasma Clusterin - A Putative PTM Marker of Alzheimer's Disease

摘要

Analysis of immunoprecipitated clusterin creates a unique glycopeptide reference resource for clusterin. Site specific glycosylation of plasma clusterin may represent a novel biomarker for Alzheimer's disease. Further biomarker potential becomes apparent by considering the relative abundance of all glycoforms identified at distinct glycosylation sites within the amino acid sequence of clusterin.