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Mass Spectrometric Analysis of Retinoid Binding Protein Receptor Substrate Specificity

机译:类视黄素结合蛋白受体底物特异性的质谱分析

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1. Mass spec based-assay is an extremely sensitive retinoid analysis method. 2. Retinoid exchange from holo-RBP is enhanced in the presence of STRA6 and it is an isomer specific phenomenon. 3. Retinoid uptake (release) is also enhanced in the presence of STRA6 and it is an isomer-specific phenomenon. 4. Enhanced retinoid uptake could be responsible for anti-cancer activity in certain cancer cells that overexpress STRA6.
机译:基于质量的质谱是一种极其敏感的类视网膜分析方法。 2.在sra6的存在下,从holo-rbp的类视黄醇交换增强,它是异构体特异性现象。 3.在SRA6存在下,类化醇摄取(释放)也增强,并且它是一种特异性现象。 4.增强的类视黄醇摄取可能是过度表达STRA6的某些癌细胞中的抗癌活性。

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