Extraction of Drugs in Plasma by Automated Liquid-Liquid Extraction For Downstream Analysis

摘要

Automated liquid-liquid extraction readily optimizes LLE conditions and yields less variable results for large numbers of analyses. Automated LLE and serial dilutions demonstrated using the Agilent 7696A Sample Prep WorkBench for bioanalytical workflow. The high sensitivity of 6490 Triple Quadrupole Mass Spectrometer is able to achieve sensitivity < 1 pg/mL. Reproducibility studies shows good LLE extracted from 50 samples. LLE using glass vials is advantageous over plastic vials. Removable vials racks in the WorkBench helps to easily transport and place vials in 1290 autosampler.