Monosodium urate (MSU) crystals are the stimulating agent of gout, which is one of the most common causes of inflammatory arthritis in men. The murine air pouch is bursa-like space that resembles the human synovial membrane. Injection of MSU crystals into pouch induces an acute inflammatory response similar to human gout flare. In early study, the mRNA microarray data shows the synovial lining cells after MSU crystals were injected into a murine air-pouch, the tissue were response to gouty inflammation. In this study, the iTRAQ-based quantitative approach was used to identify differentially expressed proteins in murine air pouch membrane, and they could serve potential biomarkers for the acute gout.
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