Criteria for Performing a Scientifically Meaningful Lipemic Plas Plasma Test during LC-MS/MS Bioanalytical Method Validation (BMV): Which Plasma Type tMS/to Choose?

摘要

Plasma from high-triglycerides donors best reflects lipemic incurred samples that may be obtained as part of clinical trials. 1. Evaluation of lipids in plasma is not done systematically on all subject enrolled. 2. A volunteer can be enrolled as a healthy volunteer and present above average levels of triglycerides. High-triglycerides donors plasma samples should be used to perform a scientifically meaningful lipemic plasma test for BMV. 1. Due to the large inter-lot variability in lipid content, only those which have a sufficient triglycerides concentration should be used.