SECONDARY ION MASS SPECTROMETRY REVEALS A DIFFERENT COMPOSITION AND DISTRIBUTION OF MOLECULES IN HUMAN NORMAL AND OSTEOARTHTRITIC CARTILAGE

摘要

Osteoarthritis (OA) is a pathology strongly linked with obesity. Many lipid mediators have been described as contributors to the OA development. In addition, cell death, extracellular matrix (MEC) remodelling and the imbalance in the ion pumps and ion channels across membranes, contribute to the cartilage degradation. Currently, we do not yet completely understand all the factors that are responsible for initiating the degradation and the loss of the joint tissues even though the main cellular pathways involved in the development of the disease have been studied extensively. The knowledge of the dynamic distribution and the variation of molecules in the different phases of the OA from a spatial point of view, is essential to understand the principal actors implicated in OA development and to look for efficient treatments.