A New Approach using Solvent Assisted Inlet Ionization for High Throughput Analysis, Surface Analysis, and Liquid Chromatography-Mass Spectrometry

摘要

Solvent assisted inlet ionization (SAII) produces ESI-like analyte ions with high sensitivity without the need of voltage, a laser, or supplied nebulizing gas. SAII-MS shows potential for high throughput analyses, ambient surface analysis, and LC/MS and MS/MS using commercially available collision induced dissociation (CID). Here we discuss some of the fundamentals of inlet ionization and demonstrate the potential utility for clinical analyses, the utility and sensitivity of SAII-MS at nanoliter flow, and the potential for surface analysis/imaging using laser ablation for dislodging tissue into the SAII solvent flow for inlet ionization.