Enhancing Quantitative Precision and Accuracy in Complex 'Systems' utilizing Advanced Informatics and a Highly Selective and Orthogonal Analytical Workflow

摘要

1. In the analysis of complex "systems" many perceived unique signals are actually composite signals. 2. Accurate assessment of quantitative change "requires" knowledge of how precise each ion has been measured. 3. Un-biased (all ion) HDMS~E acquisitions and advanced informatics provide the means to measure how well each ion has been measured in the 4 measured dimensions of m/z, tr, td and area. 4. Ion Purity scores can be utilized to filter which ions are capable of calculating highly accurate quantitative measurements across the widest dynamic ranges.