Different imaging technologies (e.g. microscopy, imaging MS, MRI, CT,...) employ different underlying principles, each with its own advantages and disadvantages. We show that these imaging modalities can be mathematically combined or 'fused' into a single pseudo-modality for the same tissue section. The image fusion result exceeds what an individual modality can deliver, yielding computer- generated images that combine individual advantages of the member - modalities, while leaving modality- specific weaknesses and noise behind. We illustrate this on brain and kidney tissue by fusing a modality that is high on spatial resolution and low on chemical information (microscopy) with a modality that is low on spatial resolution but high on chemical information (IMS), producing estimated ion images whose spatial resolution exceeds the original IMS resolution.
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