Joint analysis and mapping of metabolomics and transcriptomics changes onto biological pathways

摘要

1. We analyzed metabolomics and genomics data together and mapped differential entities on common biological pathways. 2. Selenium pathways and the metabolismofnucleotides were among the significant pathways effected by rapamycinin HEK293cells. 3. A comprehensive listof accurate mass entities from specific pathways can becreated using Agilent Pathway Metabolite Database Creatortomine raw LCMS data 4. Common biological pathways between genomics and metabolomics provide tools for further studies suchas specific targeted analysis of metabolite changes in biological processes using a triple quadrupole mass spectrometer.