Method for obtaining integrated genomic, transcriptomic, proteomic and/or metabolomic information from a single unique biological sample

摘要

The invention provides a method for the generation of integrated genomic, transcriptomic, proteomic and/or metabolomic information from single unique biological samples. It includes the separation and purification of biomolecular components including polar and non-polar metabolites, genomic DNA, RNA and proteins from said samples. The invention allows the identification of associations between different biomolecules and genetic variants in heterogeneous cell populations. It further allows the establishment and quantification of cell population profiles in heterogeneous cell populations and/or in populations where the genomic context is unknown.