MALDI-MS: a new tool for the analysis of neutral metallo-supramolecular architectures

摘要

In this study, a new protocol especially adapted to the characterization of neutral [2×2] metallo-grids has been successfully developed. Asa rule: 1) THAP has been considered as the best matrix candidate, 2) the layered sample method has been selected, 3) only data generated by the sum of the 5 first shots ona given position have to be considered. Owing to this new protocol, 24 neural metallo-supramolecular grid-types have been unambiguously characterized. We have demonstrated for the first time the feasibility of characterizing neutral supramolecular architectures by MALDI. More, it was possible to exploit this new technique to have relative stability knowledges. However, this is not a universal protocol for the characterization of non-covalent organometallic architectures: the choice of the matrix, the sample deposition preparation and instrumental parameters are strongly related to the non-covalent assemblyofinterest.