CHARACTERIZATION OF MALONDIALDEHYDE MODIFICATIONS OF APOLIPOPROTEIN A-1 IN ITS HDL ENVIRONMENT

摘要

Three lysine sites 12, 59 and 238 of apolipoprotein A-1 are the first sites to be modidfied by MDA in vitro. The mono-MDA adduct forms first at lower MDA concentrations; the DHP adduct was observed at higher MDA concentrations.