A rapid detection and identification of impurities in ten 2-Naphthalenamines using atmospheric pressure solids analysis probe in conjunction with ion mobility mass spectrometry

摘要

This work has demonstrated a new approach for impurity profiling study by using ASAP in conjunction with ion mobility and time-of-flight mass spectrometry. The combination of the ASAP and TOF-IM-MS enables a quick analysis within a couple of minutes to achieve a fingerprint of the impurity profile since a LC separation was removed. Sufficient separation of protonated molecules according to their m/z values in ion mobility cell brings a significant complement to the absence of LC chromatographic separation in the analysis. The comparison of ESI and ASAP data for the impurity profiling study of the ten 2-Naphthalenamines reveals that ASAP with corona discharge pin ionizes a wider range of compounds than ESI. This is due to ASAP involving APcI-like ionization mechanism, which ionizes not only polar compounds but also non-polar compounds. The hyphenation of ASAP and IM-MS techniques represents a highly efficient approach for rapid detection and identification of impurities generated in complex reactions involved in pharmaceutical process development.