Tandem Gas Chromatographic-Mass Spectrometric (GC/GC/MS) Analysis of Soman-Plasma Protein Adducts as Nerve Agent Biomarkers in Cynomolgus Macaques Using Fluoride Regeneration

摘要

The results from this study are evidence for the validation for a sensitive, precise, and accurate method for quantitation of GD exposure using plasma protein biomarkers. The application of this method to two animal studies suggests that BuChE acts as an effective bioscavenger for GD exposure.