A novel automated 2D-LCMS-IT-TOF system compatible with non-volatile salts applied to accelerating impurity ID workflow in chemistry, manufacturing and controls

摘要

2D LC-IT-TOF system accelerates method transfer to high mass accuracy MS analysis and can be a key technology in impurity analysis. (1) Supports non-volatile LC separations developed as part of standard test methods. (2) Simplifies impurity detection by comparing UV chromatograms. (3) Integrated transfer to structure elucidation by accurate mass MS~(n) measurement and significantly reduced workloads in impurity identification.