Paper spray has been developed as a fast, direct and low-cost sampling ionization method for MS analysis of complex mixtures and has been applied for direct analysis of dried blood spot and tissue samples. The low cost in production of paper as sample substrates, demonstrated chemical separation with paper chromatography, and the potential in coupling with paper microfluidics, make the paper spray attractive for making disposable devices that have integrated on-line sample treatment and direct ionization for mass spectrometry analysis. In this study, the fluidic features involved in the design of paper spray devices were studied and characterized. Methods for fabricating paper spray devices with different functions were developed.
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