Quantitative Cross-Species Comparison of Global Histone H3 Modification States between Drosophila melanogaster and Homo sapiens Using SILAC

摘要

Global cross-species comparison of D. melanogaster and H. sapiens demonstrates a variable epigenetic landscape. Of the analyzed modification sites, 6 of 8 differed between the two species. While much homology exists between the histone modification and recognition complexes of these two species, other factors contribute to the regulation of methylation and acetylation.