PROTEOMIC ANALYSIS OF PROTEIN PHOSPHORYLATION IN THE RENAL RESPONSE TO METABOLIC ACIDOSIS

摘要

Metabolic acidosis is a common clinical condition that is caused by a decrease in the blood pH and the concentration of bicarbonate. An adaptive response to metabolic acidosis, which results from pronounced changes in gene expression, occurs in the proximal convoluted tubule cells of the kidneys. When metabolic acidosis occurs, a physiological consequence is an adaptive response in the proximal convoluted tubule cells in the kidney. Within these cells increased renal catabolism of glutamine leads to release of bicarbonate ions to the blood and ammonia ions to restore the acid-base balance. Adaptations based on changes in gene expression within the proximal tubule occur and are controlled by post-translational modifications, frequently involving changes in protein phosphorylation.