Matrine Blocks the Autophagic Degradation via Trafficking Process of Lysosomal Components

摘要

1) Matrine blocks the autophagic degradation step via inhibition of the proteinases activities in lysosomes. 2) Matrine may affect the phosphorylation status of GAPDH in SGC7901 3) The distribution of pro/mature Cathepsin D was changed due to the Matrine treatment, suggesting this drug could regulate the ER-Golgi trafficking process.