DIAGNOSIS TREATMENT OF HEPATIC FIBROSIS - CHALLENGES EMERGING STRATEGIES

摘要

The clarification of the mechanisms of fibrosis has led to a surge in enthusiasm for treating hepatic fibrosis, and animal models strongly support the rationale of this approach. In fact, much like the paradigm of cancer treatment, success to date inanimal models has been far easier to achieve than in human trials, possibly because the duration of injury and extent of matrix deposition and cross-linking is greater in humans. Key obstacles remain to be overcome before antifibrotic therapies can reachwidespread clinical use.