Fast loading, slow release--a new strategy for incorporating antibiotics to hydroxyapatite

摘要

The aim of this study was to investigate if it is possible to fast load hydroxyapatite with antibiotics and still obtain a slow but therapeutic release of drugs during several hours. Physical vapour deposition was used to coat commercially pure titanium with a layer of anatase TiO_2. On top of this, a layer of hydroxyapatite was deposited using biomimetic precipitation. This hydroxyapatite coating was then soaked in solutions containing antibiotics for various amounts of times. The release rate of the antibiotics was measured in PBS during 22 hours. The released amount was compared with the results from an antimicrobial susceptibility test and proved to be sufficient to kill several ml of bacterial broth during the time of the release measurements. It was shown that the soaking time does not affect the release rate and the results suggest that it is possible to develop implants with the option to add antibiotics to their surface at the site of surgery by a simple soaking method.