Design of an Automated System for Synthesis of 18F FDG for PET Investigation at IFIN-HH Bucharest

摘要

A novel apparatus constructed at IFIN-HH is described for automated synthesis of radiopharmaceuticalslabeled with 18F for use in positron emission tomography (PET) investigations. [18F] fluoride was produced at the IFIN-HH cyclotron by irradiation of H20 enriched 97% in 180 with 13 MeV deuterons, or 8 MeV protons. The irradiated H20was transferred (injected) into the radiochemical fully-automated processing systems which ensured the separation of 18Ffrom H20, the labeling with 18F, and finally purified by filtration with selective absorbants. The system is easy to operateand contains a programmable logical controller that manages the entire operation program stored in its internal memory.The computer is used to assist the operator during the different steps of synthesis and to allow visualization of theprocess and printing the report. The device was used for used for the production of 2418F1 FLUORO-2-DEOXY-D-GLUCOSE at the IFIN-HH cyclotron, one of the most used radiopharmaceutical in PET investigations. The synthesismodule is configured so that is flexible enough to accomplish other nucleophile reactions of labeling with short livedradioisotopes.