Design, Synthesis and Applications of Cell-penetrant Peptides as Signal Transduction Modulators

摘要

The regulatory and catalytic domains of intracellular proteins are common targets for experimental manipulations. Protein-protein interactions are also a fundamental feature of signal transduction pathways that control a broad range of cellular activities. Agents that specifically mimic or inhibit interactions between signal transducing proteins are, therefore, valuable research tools with proven clinical utility. Moreover, the development of agents capable of manipulating signaling events may also promote the discovery of additional protein binding partners that represent novel drug discovery targets.