Microwave-Assisted Synthesis of a Glycine-Rich Difficult Peptide Sequence, the C-terminal Amidated Portion of Acanthoscurrin

摘要

Besides studying chemistry, structure and mode of action of antimicrobial peptides (AMP), we have been investigating solid-phase peptide synthesis (SPPS) at elevated temperatures. We have shown that our protocols at 60°C using conventional heating are effective and economical for high-speed stepwise synthesis of a variety of peptides by Fmoc or Boc strategy [1]. We have also demonstrated the adequacy of such protocols to microwave-assisted SPPS [2].