~(99m)Tc-labeled Ac-DEVD Peptides as a Substrate for Measuring Caspase Activity

摘要

Caspases are a structurally related group of cysteine proteases that cleave peptide bonds following specific recognition sequences. The activation of caspases is a hallmark of apoptosis. Objective and quantitative noninvasive imaging of apoptosis would be a significant advance for rapid and dynamic screening as well as validation of experimental therapeutic and diagnostic agents.