Ion Channel Formation of Dimeric Peptide Enhanced by Electrostatic Inter-Helical Interactions

摘要

Helical ion channel forming peptides are simplified models of ion channel proteins. Appropriate assembly of helical peptides and stable pore structures has been pursued for artificial ion channel design. Several helix oligomerization techniques have been suggested as methods to construct stable and optimal pore structures [1, 2]. For example, peptide dimerization has been used to investigate relationships between structure and ion channel function for artificial ion channel design.