Photophysical and photochemical properties of a-(8-quinolinoxy) zincphthalocyanine for photodynamic therapy

摘要

The photophysical and photochemical properties of a newly developed photosensitizer a-(8-quinolinoxy) zinc phthalocyanine (α-(8-QLO)PcZn) were investigated for application in photodynamic therapy (PDT). The maximal Q band for α-(8-QLO)PcZn in dimethylformamide around 675 nm with the molar extinction coefficient of about 1.89×10~5 mol~(-1) cm~(-1) . The fluorescence quantum and singlet oxygen (~1O_2) yields were determined to be 0.18±0.02 and 0.62±0.03, respectively. α-(8-QLO) PcZn has a diffuse cytoplasmic distribution in nasopharyngeal carcinoma C666-1 cells, and the efficient photodynamic cytotoxicity was observed. Our findings of this study suggest that a-(8-QLO)PcZn is a promising second-generation photosensitizer for PDT.