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From Bench to Bedside: Surgery for Lung Cancer

机译:从长凳到床边:肺癌手术

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Lung cancer has recently become the number-one cause of cancer deaths worldwide. The predicted death from non-small cell lung cancer is 162 460 in 2006 in USA. Patients with metastasis or N2/3 disease have dismal prognosis and resectional surgery is generally futile in these subsets. On the another hand, earliest stages indicated better survivals which were not satisfactory. Patients with cIA tumor have 61% 5-year survival, whereas the 5-year survival of cases with pIA tumors is 67% (1). However, patients with earliest stage breast or thyroid cancer have excellent survival probabilities while late stages of these disease indicated poor survival rates (2,3). For these reasons, despite the 6 consecutive staging system, lung cancer staging needed revisions in order to provide more realistic stratifications depending on the T, N and M parameters. New (7th) staging system proposal promises more informative classification(4). International Association of for the Study of Lung Cancer (IASLC)analyzed total of 100.869 patients from 19 countries. They also used 'recursive partitioning' as a state-of-the-art statistical method(4,5). The T factor classification was also proposed to be revised. T1 status is divided into T1a and T1b, T2 is divided into T2a, T2b. Despite all improvements, 5-year survival rate was 73% in IA patients.
机译:肺癌最近成为全世界癌症死亡的第一原因。来自非小细胞肺癌的预测死亡于2006年在美国是162 460。转移或N2 / 3疾病的患者具有令人沮丧的预后和切除手术在这些子集中通常是徒劳的。另一方面,最早的阶段表明了更好的幸存者,这些幸存者并不令人满意。 CIA肿瘤的患者具有61%的5年生存率,而PIA肿瘤病例的5年生存率为67%(1)。然而,最早患者乳腺或甲状腺癌的患者具有优异的存活概率,而这些疾病的晚期阶段表明存活率差(2,3)。由于这些原因,尽管连续6个连续的分期系统,肺癌分期需要修订,以便根据T,N和M参数提供更现实的分层。新(7)分期系统提案承诺更具信息丰富的分类(4)。国际肺癌研究协会(IASLC)分析了19个国家的100.869名患者。它们还将“递归分区”用作最先进的统计方法(4,5)。还提出了修订T因子分类。 T1状态分为T1A和T1B,T2分为T2A,T2B。尽管存在所有改善,但患者患者5年的存活率为73%。

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