Regulation of Stem Cells in the Zebra FishHematopoietic System

摘要

Hematopoietic stem cells (HSCs) have been used extensively as a model for stem cell biology. Stem cells share the ability toself-renew and differentiate into multiple cell types, making them ideal candidates for tissue regeneration or replacement ther-apies. Current applications of stem cell technology are limited by our knowledge of the molecular mechanisms that controltheir proliferation and differentiation, and various model organisms have been used to fill these gaps. This chapter focuses onthe contributions of the zebra fish model to our understanding of stem cell regulation within the hematopoietic system. Studiesin zebra fish have been valuable for identifying new genetic and signaling factors that affect HSC formation and developmentwith important implications for humans, and new advances in the zebra fish toolbox will allow other aspects of HSC behaviorto be investigated as well, including migration, homing, and engraftment.