Patients with hemophilia were at high risk of acquiring blood-borne infections transmitted by factor VIII or factor IX concentrates which were not virus inactivated before 1986.The occurrence of Hepatitis C (HCV)-related liver cirrhosis and the development of hepatocellular carcinoma (HCC) is a major problem in patients with hemophilia A. Up to 30% of patients with hepatitis C infection will develop liver cirrhosis [1].Liver transplantation has been shown to give the patients a long-term benefit. The first successful orthotopic liver transplantation in a patient with hemophilia has been reported in 1985 [3].Nevertheless transplantation of a patient with coagulation disorders remains challenging especially if hemophilia is combined with any further coagulative disorder.
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