CYCLOSPORINS THE HEMOSTATIC SYSTEM: IS THE DRUG SAFE IN IMHA PATIENTS?

摘要

Immune-mediated hemolytic anemia (IMHA), a common cause of anemia in dogs, results from the antibody-mediated destruction of circulating red blood cells. Unfortunately, despite our best efforts, mortality rates for canine IMHA are still unacceptably high. Most large retrospective and prospective studies of dogs with IMHA cite patient mortality rates of around 50% (range 25% to 70%), and mortality rates have not really improved much at all over the past few decades. The majority of canine patients that either die naturally or are euthanatized because of IMHA die within the first few weeks of diagnosis, and the largest cause of death is thrombotic disease, particularly pulmonary thromboembolism (PTE). In fact, the incidence of pulmonary