BEYOND NT-PROBNP: ALTERNATIVE BIOMARKERS OF CARDIAC DISEASE

摘要

The focus of the previous lectures on NT-proBNP highlights the excitement of cardiac biomarkers along with the challenges of finding the ideal biomarker or the ideal cut-off point(s). Currently the natriuretic peptides are regarded as the most promising circulating biomarkers in our patient populations, but there are many other markers that can be used in the evaluation of these patients There are markers of myocyte stress like adrenomedullin and ST2, markers of myocyte injury including the cardiac troponins, markers of inflammation (e.g. C-reactive protein, TNF-a, interleukin 1 and 18), markers of remodeling including the matrix metalloproteinases and tissue inhibitors of metalloproteinases, and many others including the neurohumoral markers. The various application and