The expression of COX-2 and TRX-1 in breast cancer and the correlation with prognosis

摘要

@@Introduction:Many studies indicated that over-expression of cyclooxygenase-2 (COX-2) was correlated with occurrence and development of many solid cancers (such as colorectal cancer, lung cancer, ect.). Over-expression of COX-2 protein in cancers was likely to occur via several different mechanisms involving complex signaling pathways. Over-expression had been associated with a poor clinical outcome. High incidence rates of over-expression COX-2 was also found in breast cancer patients. At present although we used selective inhibitor to improve prognosis, the angiomyocardiac adverse effect constrained the serviceable range. Furthermore the curative effect was not sure. So if we could inhibit expression of upstream control factors, it would be better for downregulation of COX-2. But now the mechanism of regulation was not clear.