This work aims to produce porous biopolymer particles for pharmaceutical applications. In particular chitosan and chitosan ibuprofen-loaded particles are being produced through supercritical CO_2-assisted atomization in a SAA laboratory scale apparatus at NOVA and in a pilot scale PGSS drying apparatus at BOCHUM. Particles were obtained in the range of 2 μm to around 1 mm. Chitosan particles were further impregnated in a batch reactor in scCO_2 and the drug uptake and release profiles compared with the chitosan-ibuprofen co-atomization formulation. The drug release profiles were evaluated by in vitro experiments at PBS pH 7.4 and 37°C. Preliminary results show that the way of loading the particles influence both the impregnation degree of the drug and the release profiles of the formulations.
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