IMPINGING JETS APPLIED TO SULFATHIAZOLE CRYSTALLIZATION USING SUPERCRITICAL ANTISOLVENT (SAS) PROCESS

摘要

The aim of this study is to improve mixing in supercritical antisolvent process (SAS) with impinging jets in order to form finer particles. The influence of several process parameters variations upon sulfathiazole crystallization, a poorly water-soluble drug, is studied. Parameters are jets velocity (0.25m/s to 25.92m/s), temperature (313K to 343K), pressure (10MPa to 20MPa) and sulfathiazole concentration in the organic solution (0.5% to 1.8%). Crystallized powders show that particle size, size distribution and morphology are different from the ones obtained with classical SAS introduction device in similar conditions. The mean particle size and the size distribution are significantly smallest than results obtained with classical SAS. Different polymorphs are obtained, including the pure stable one.