Computational study on superparamagnetic hyperthermia with biocompatible SPIONs to destroy the cancer cells

摘要

Superparamagnetic hyperthermia (SPMHT) appears nowadays as the most promising method of the future, non-invasive and with low toxicity, for destroys the cancer cells through the magnetic relaxation in superparamagnetic nanoparticles.In our research we focused on finding the optimal conditions using a 3D computational study to obtain a maximum specific absorption rate (SAR) by the magnetic relaxation in Fe_3O_4 and γ-Fe_2O_3 superparamagnetic iron oxide nanoparticles (SPIONs), which give the most pronounced SAR and with low toxicity on cells.The effect of the diameter of the nanoparticles, frequency and amplitude of external alternating magnetic field and the thickness of biological coating of nanoparticles in the case of their encapsulation in biocompatible membranes, like liposomes (Ls) and cyclodextrins (CDs), on Néel-Brown magnetic relaxation and maximum SAR, are presented and discussed in this paper, within the biological admitted limit.