Effectiveness of microstructured interface for percutenous devices was studied by a rat model. The model device was prepared by adhering a machined PMMA rod of 10-mm diameter and 6-mm height with a circumference groove and a 0.2-mm thick PMMA sheet with 10 rows x 100 columns of 200-um laser-processed holes. The sheet was placed over the groove and thus provided a microstructured interface for mechanical attachment. Similar specimens without laser-processed holes were also prepared and used as controls. The specimens were implanted into dorsal skin of rats for 4 weeks. The attachment test and histological observation was carried out for the retrieve specimens. The attachment strength of the devices with microstructured interface was evaluated as 3.59 ± 3.93 N (n = 10), that was statistically greater than that of controls. Mechanical attachments of tissues were confirmed in histological observations. Thus the effectiveness of the microstructured interface was demonstrated.
展开▼
