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A Cyber-Physical Framework for MRI Guided Magnetic Nano/Micro particles Called 'MAGNASIM'

机译:用于MRI引导磁性纳米/微粒的网络物理框架,称为“Magnasim”

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Nano Magnetic Particles drug delivery is a new method of cancer treatment targeting the replacement of current methods such as chemotherapy and radiation to increase the efficiency of treatment. This project aims to design a system including experimental setup and computational platforms that will work parallel to each other developing guidelines for scientists. The Computational platform is able to model the nano particle's aggregations and movement. Experimental setup will be used to generate results validating the simulations done on the computational platform. Experimental setup has the potential to operate Magnetic nanoparticles drug delivery in different scale and situations. We aim to make the experimental setup as close as possible to human blood properties. This will enable us to come up with guiding trajectories and control algorithms for guidance of different size and shape nano particles in arbitrary capillary shapes. This data can be beneficial for researchers doing experiments on magnetic drug delivery and avoid the In vivo experiments for the sake of animal rights. We present software called MAGNASIM that is being developed to perform simulation, visualization and post-processing analysis of the aggregation and disaggregation processes of magnetic Nano/Micro particles within a fluid environment such as small arteries and arterioles or fluid-filled cavities of the human body. Basically the software would be able: 1. To examine Self-assembly process and breakup process 2. To provide design guidelines for fabricating, control and steering the nanocapsules After gathering all the initial conditions, software is able to provide the user the following information: 1. Forces on each particle in each time-step. 2. Position of each particle in each time-step. 3. Interactions between particles. 4. Control and steer the particles to the considered destination. 5. Providing visualization of the particles movement.
机译:纳米磁性颗粒药物递送是一种新的癌症治疗方法,其靶向替代电流方法,如化疗和辐射,以提高治疗效率。该项目旨在设计一个系统,包括实验设置和计算平台,该计算平台将与彼此的科学家互相开发的制定指南。计算平台能够模拟纳米粒子的聚集和运动。实验设置将用于生成验证在计算平台上所做的模拟的结果。实验设置具有在不同规模和情况下操作磁性纳米颗粒的药物递送。我们的目标是使实验设置尽可能接近人类血液性质。这将使我们能够提出引导轨迹和控制算法,以便在任意毛细管形状中引导不同尺寸和形状纳米颗粒。该数据对于研究人员对磁药递送进行实验并避免体内实验,可以为动物权利进行实验。我们呈现称为Magnasim的软件,该软件正在开发,以进行磁性纳米/微颗粒在流体环境中的聚集和分解过程的模拟,可视化和后处理分析,例如人体的小动脉和动脉源或流体填充空腔。基本上该软件能够:1。检查自组装过程和分手过程2.提供用于在收集所有初始条件后制造,控制和转向纳米胶囊的设计指南,软件能够为用户提供以下信息: 1.在每个时间步骤中的每个颗粒上的力。 2.每个颗粒在每次步骤中的位置。 3.粒子之间的相互作用。 4.控制并将粒子转向到所考虑的目的地。 5.提供粒子运动的可视化。

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