A Cyber-Physical Framework for MRI Guided Magnetic Nano/Micro particles Called 'MAGNASIM'

摘要

Nano Magnetic Particles drug delivery is a new method of cancer treatment targeting the replacement of current methods such as chemotherapy and radiation to increase the efficiency of treatment. This project aims to design a system including experimental setup and computational platforms that will work parallel to each other developing guidelines for scientists. The Computational platform is able to model the nano particle's aggregations and movement. Experimental setup will be used to generate results validating the simulations done on the computational platform. Experimental setup has the potential to operate Magnetic nanoparticles drug delivery in different scale and situations. We aim to make the experimental setup as close as possible to human blood properties. This will enable us to come up with guiding trajectories and control algorithms for guidance of different size and shape nano particles in arbitrary capillary shapes. This data can be beneficial for researchers doing experiments on magnetic drug delivery and avoid the In vivo experiments for the sake of animal rights. We present software called MAGNASIM that is being developed to perform simulation, visualization and post-processing analysis of the aggregation and disaggregation processes of magnetic Nano/Micro particles within a fluid environment such as small arteries and arterioles or fluid-filled cavities of the human body. Basically the software would be able: To examine Self-assembly process and breakup process To provide design guidelines for fabricating, control and steering the nanocapsules After gathering all the initial conditions, software is able to provide the user the following information: 1. Forces on each particle in each time-step. 2. Position of each particle in each time-step. 3. Interactions between particles. 4. Control and steer the particles to the considered destination. 5. Providing visualization of the particles movement.