NOVOKININ, AN ANGIOTENSIN AT2 AGONIST PEPTIDE, DECREASES FOOD INTAKE IN MICE

摘要

There are two receptor subtypes for angiotensin II: AT1 and AT2 receptor, which is known to mediate hypertensive and hypotensive activity, respectively. Novokinin (RPLKPW) is an agonist for AT2 receptor, which has been designed by replacing 4 amino acids in a vasorelaxing hexapeptide ovokinin(2-7) (RADHPF) derived from ovalbumin. We previously reported that novokinin relaxed blood vessels and reduced blood pressure after oral administration through AT2 receptor. Recently, we also found that novokinin stimulates hair growth and prevents alopecia induced by anti-cancer drug. In this study, we found that novokinin and angiotensin analogues suppress food intake via AT2 receptor.