SECONDARY STRUCTURAL ELEMENTS AND INTRAMOLECULAR H-BONDING PATTERNS OF POLY-(ALA) AND POLY-(GLN) PEPTIDES

摘要

Homopolymeric amino acids (HPAAs) are polypeptides consisting of the same amino acids. Some of them play a relevant role in the formation of several neurodegenerative diseases. Most probably the poly-(Ala) and poly-(Gln) are the best representatives of these peptides because of their important biological effects. Therefore, our aims were to perform conformational analysis and to investigate the secondary structural elements as well as intramolecular H-bonding patterns of these two HPAAs.