Catalytic Hydrogenation of a Schiffs Base over Pd/Carbon Catalysts: Kinetic Prediction of Impurity Fate and Byproduct Formation

摘要

In situ reduction of Schiffs bases is a common reaction used in the preparation of pharmaceutical intermediates. Muraglitazar (PPAR a/y dual agonist) is being evaluated for the treatment of type II diabetes. We have recently carried out a large scale hydrogenation of an imine, prepared through the condensation of an aromatic aldehyde with an amine, to produce the final intermediate in the muraglitazar synthesis. Studies were carried out for better process understanding. We present a kinetic analysis using the Langmuir-Hinshelwood approach to model the complex reaction network. This knowledge has led to process conditions that minimize the formation of potential impurities, resulting in a more robust process.