APPLICATION OF ISOTOPE-LABELING IN WHOLE-BODY DESI-MSI STUDIES FOR INTRA-ANIMAL COMPARISON OF DRUG ADMINISTRATION ROUTES

摘要

The distribution of an administered drug in the organism is highly dependent on the administration route as well as the drug formulation. Therefore, assessing the distribution and metabolism of drug substances or drug candidates is of great importance in drug development, and mass spectrometry imaging has demonstrated many advantages, in particular due to its unique selectivity which enables specific imaging of several exogenous and endogenous compounds simultaneously.