LOW-FLOW ATMOSPHERIC PRESSURE CHEMICAL IONIZATION BASED ON A GAS DYNAMIC VIRTUAL NOZZLE NEBULIZER

摘要

Atmospheric pressure chemical ionization (APCI) is a useful tool for analyzing small and relatively stable molecules, e.g. lipids [1], at milliliter-per-minute sample flow rates. Despite the previous effort to develop low-flow APCI [2,3], no such an ion source has been commercialized yet. We are currently developing a nebulizer for an APCI source operable at sub-microliters per minute flow rates.