KINETICS OF A CLICK REACTION IN CHARGED MICRODROPLETS WITH TIME RESOLVED REACTIVE LASER ABLATION ELECTROSPRAY IONIZATION MASS SPECTROMETRY

摘要

Time resolved mass spectrometry (TRMS) provides insights into fundamental processes in (bio)molecular reactions, such as the direct detection of short-lived intermediates and the acquisition of kinetic data. Laser ablation based injection coupled to electrospray ionization (LAESI) can be used as a novel TRMS method to perform reactions in charged microdroplets, e.g. to accelerate synthesis or to study the chemistry of life.