STRUCTURAL ELUCIDATION OF METABOLITES USING INFRARED ION SPECTROSCOPY

摘要

The identification of molecular biomarkers is critical for diagnosis, treatment and for establishing a fundamental understanding of the pathophysiology and underlying biochemistry of inborn errors of metabolism. We show that, using the free electron laser FELIX and a modified Bruker ion trap, infrared ion spectroscopy (IR-IS) is a powerful technique for identifying metabolites. We also show that with our HPLC we can now investigate complex body fluid samples.